{"id":8529,"date":"2020-03-07T11:43:42","date_gmt":"2020-03-07T09:43:42","guid":{"rendered":"https:\/\/havas.cz\/?post_type=pressroom&p=8529"},"modified":"2020-10-14T10:13:14","modified_gmt":"2020-10-14T08:13:14","slug":"lecba-hereditarniho-angioedemu-minulost-soucasnost-a-zlomova-blizka-budoucnost","status":"publish","type":"pressroom","link":"https:\/\/havas.cz\/en\/pressroom\/lecba-hereditarniho-angioedemu-minulost-soucasnost-a-zlomova-blizka-budoucnost\/","title":{"rendered":"L\u00e9\u010dba heredit\u00e1rn\u00edho angioed\u00e9mu \u2013 minulost, sou\u010dasnost a zlomov\u00e1 bl\u00edzk\u00e1 budoucnost"},"content":{"rendered":"

P\u0159edpokladem pro vznik heredit\u00e1rn\u00edho angioed\u00e9mu je nej\u010dast\u011bji d\u011bdi\u010dnost. Pravd\u011bpodobnost projevu onemocn\u011bn\u00ed u potomka je 50\u00a0%.5<\/sup> Ve v\u011bt\u0161in\u011b p\u0159\u00edpad\u016f je d\u016fvodem genov\u00e1 mutace, kter\u00e1 m\u00e1 za n\u00e1sledek nedostate\u010dnou tvorbu inhibitoru C1\u2011ester\u00e1zy (C1\u2011INH). Pacienti trp\u00edc\u00ed HAE maj\u00ed bu\u010f sn\u00ed\u017eenou hladinu C1-INH, nebo C1-INH proteinu, kter\u00e9 nefunguj\u00ed spr\u00e1vn\u011b. P\u0159i atace HAE nen\u00ed protein C1-INH schopen zabr\u00e1nit p\u0159\u00edli\u0161 vysok\u00fdm hladin\u00e1m bradykininu a slo\u017eek komplementov\u00e9ho syst\u00e9mu. Jsou-li hladiny t\u011bchto slo\u017eek vysok\u00e9, vzr\u016fst\u00e1 propustnost krevn\u00edch c\u00e9v, co\u017e dovoluje tekutin\u00e1m pronikat do okoln\u00ed tk\u00e1n\u011b a n\u00e1sledn\u011b vede k otok\u016fm, bolestem a v\u00a0p\u0159\u00edpad\u011b otok\u016f oblasti hrtanu nap\u0159\u00edklad i k nepr\u016fchodnosti d\u00fdchac\u00edch cest.6<\/sup><\/p>\n

Po\u010d\u00e1tky diagnostiky HAE<\/strong><\/p>\n

Na po\u010d\u00e1tku l\u00e9ka\u0159i heredit\u00e1rn\u00ed angioed\u00e9m spojovali s\u00a0kop\u0159ivkou. Tyto zm\u00ednky najdeme v\u00a0textech poch\u00e1zej\u00edc\u00edch z\u00a0\u010c\u00edny asi p\u0159ed 1000 lety. Ov\u0161em prvn\u00ed z\u00e1znam o v\u00fdskytu otok\u016f jako samostatn\u00e9 klinick\u00e9 jednotce zm\u00ednil a\u017e John Milton v\u00a0roce 1876, kter\u00fd je ozna\u010dil za \u201eob\u0159\u00ed kop\u0159ivku\u201c. Zm\u00ednka o ohrani\u010den\u00e9m otoku pak poch\u00e1z\u00ed z roku 1882. Ve stejn\u00e9m roce diagnostikoval Eugen Dinkelacker 14 v\u00fdskyt\u016f tohoto onemocn\u011bn\u00ed. Ve sv\u00e9 pr\u00e1ci zmi\u0148oval pacienty s v\u00fdskytem otok\u016f na kon\u010detin\u00e1ch, obli\u010deji, laryngu a\u00a0gastrointestin\u00e1ln\u00edm traktu. Jako prvn\u00ed dok\u00e1zal rozeznat vrozen\u00e9 formy klinick\u00fdch otok\u016f od jin\u00fdch druh\u016f otok\u016f Sir William Osler v\u00a0roce 1888. Stejn\u011b tak poprv\u00e9 zm\u00ednil rodinn\u00fd v\u00fdskyt angioed\u00e9mu v p\u011bti generac\u00edch. Teprve v\u0161ak roku 1963 popsali Virginie H. Donaldsonov\u00e1 a R. R. Evans defekt C1 inhibitoru jako p\u0159\u00ed\u010dinu tohoto onemocn\u011bn\u00ed.3<\/sup><\/p>\n

Konkr\u00e9tn\u011b v \u010cesk\u00e9 republice se l\u00e9ka\u0159i za\u010dali heredit\u00e1rn\u00edmu angioed\u00e9mu v\u00edce v\u011bnovat a\u017e v\u00a0roce 2010. Do t\u00e9 doby byla p\u00e9\u010de o nemocn\u00e9 s\u00a0tolik z\u00e1va\u017enou diagn\u00f3zou rozt\u0159\u00ed\u0161t\u011bna a pacienti byli kv\u016fli r\u016fznorod\u00e9mu org\u00e1nov\u00e9mu posti\u017een\u00ed l\u00e9\u010deni na\u00a0r\u016fzn\u00fdch typech odd\u011blen\u00ed. Jedinou v\u00fdjimkou bylo brn\u011bnsk\u00e9 pracovi\u0161t\u011b \u00dastavu klinick\u00e9 imunologie a alergologie FN u sv. Anny, kde se t\u00e9to diagn\u00f3ze celo\u017eivotn\u011b v\u011bnuje MUDr. Pavel Kukl\u00ednek, CSc.7<\/sup><\/p>\n

L\u00e9\u010dba v\u00a0\u010cR a vznik center<\/strong><\/p>\n

Z\u00e1sadn\u00ed zlom ohledn\u011b l\u00e9\u010dby HAE nastal v \u010cesku roku 2011, p\u0159i vstupu inovativn\u00edho prepar\u00e1tu, kter\u00fd byl na podn\u011bt zdravotn\u00edch poji\u0161\u0165oven povolen k indikov\u00e1n\u00ed pouze v\u00a0tzv. l\u00e9kov\u00fdch centrech. D\u00edky podpo\u0159e \u010cesk\u00e9 spole\u010dnosti alergologie a klinick\u00e9 imunologie to byl popud k\u00a0vytvo\u0159en\u00ed \u010dty\u0159 center p\u0159i \u00fastavech klinick\u00e9 imunologie a alergologie fakultn\u00edch nemocnic (Praha, Brno, Plze\u0148 a Hradec Kr\u00e1lov\u00e9). Krom\u011b mo\u017enosti zde aplikovat nov\u00fd l\u00e9k bylo c\u00edlem poskytovat pacient\u016fm komplexn\u00ed l\u00e9\u010dbu.7<\/sup><\/p>\n

Spolu se vznikem center se zv\u00fd\u0161ilo i pov\u011bdom\u00ed o heredit\u00e1rn\u00edm angioed\u00e9mu a \u0161koleni byli nap\u0159\u00edklad i l\u00e9ka\u0159i pracuj\u00edc\u00ed na pohotovostn\u00edch ambulanc\u00edch dan\u00fdch fakultn\u00edch nemocnic.7<\/sup> Osv\u011bta o onemocn\u011bn\u00ed, kter\u00e9 je \u017eivot ohro\u017euj\u00edc\u00ed, v\u0161ak st\u00e1le nen\u00ed na takov\u00e9 \u00farovni, jak by bylo pot\u0159eba. Pr\u00e1v\u011b jeho vz\u00e1cnost vede k\u00a0tomu, \u017ee informovanost o n\u011bm je mnohdy n\u00edzk\u00e1 a diagn\u00f3za tak m\u016f\u017ee \u010dasto trvat i n\u011bkolik let.6<\/sup> S\u00a0t\u00edm se m\u016f\u017ee pojit i fakt, \u017ee se v \u010cesk\u00e9 republice s\u00a0heredit\u00e1rn\u00edm angioed\u00e9mem k\u00a0roku 2018 l\u00e9\u010dilo 162 pacient\u016f, co\u017e je dle p\u0159edpoklad\u016f pravd\u011bpodobn\u011b jen \u010d\u00e1st v\u0161ech p\u0159\u00edpad\u016f,8<\/sup> ale i fakt, \u017ee doch\u00e1z\u00ed k\u00a0chybn\u00fdm z\u00e1m\u011bn\u00e1m otok\u016f za alergickou reakci, a to i p\u0159esto, \u017ee ed\u00e9m nesv\u011bd\u00ed. V\u00a0p\u0159\u00edpad\u011b otok\u016f b\u0159icha m\u016f\u017ee b\u00fdt pak myln\u011b diagnostikov\u00e1n jako n\u00e1hl\u00e1 p\u0159\u00edhoda b\u0159i\u0161n\u00ed nebo p\u0159i otoc\u00edch tr\u00e1vic\u00edho syst\u00e9mu zase jako z\u00e1n\u011bt slep\u00e9ho st\u0159eva, a pacient se tak m\u016f\u017ee dostat i k\u00a0zbyte\u010dn\u011b proveden\u00e9mu chirurgick\u00e9mu z\u00e1kroku.6<\/sup> Spr\u00e1vn\u00e1 a v\u010dasn\u00e1 diagn\u00f3za nemoci je zcela z\u00e1sadn\u00ed, jeliko\u017e akutn\u00ed ataky mohou pacienta potenci\u00e1ln\u011b ohro\u017eovat na \u017eivot\u011b.7<\/sup><\/p>\n

Sou\u010dasn\u00e9 mo\u017enosti v\u00a0l\u00e9\u010db\u011b akutn\u00ed i preventivn\u00ed <\/strong><\/p>\n

P\u0159i l\u00e9\u010db\u011b HAE je nutn\u00e9 se soust\u0159edit na t\u0159i z\u00e1kladn\u00ed situace. Zaprv\u00e9, pokud ji\u017e u pacienta do\u0161lo k\u00a0rozvoji otoku, je pot\u0159eba reagovat akutn\u00ed l\u00e9\u010dbou. Zadruh\u00e9, pokud je pacient vystaven riziku otok\u016f (nap\u0159. p\u0159i chirurgick\u00e9m v\u00fdkonu), je pot\u0159eba vyu\u017e\u00edt kr\u00e1tkodob\u00e9 preventivn\u00ed l\u00e9\u010dby. Zat\u0159et\u00ed, jestli\u017ee k\u00a0otok\u016fm doch\u00e1z\u00ed p\u0159\u00edli\u0161 \u010dasto, je nutn\u00e9 sn\u00ed\u017eit riziko jejich opakov\u00e1n\u00ed dlouhodobou profylaktickou l\u00e9\u010dbou.9<\/sup> V minulosti byla l\u00e9\u010dba omezena na kyselinu tranexamovou a l\u00e9ky proti bolesti (v\u010detn\u011b morfia) u akutn\u00edch z\u00e1chvat\u016f a\u00a0anabolick\u00e9 steroidy pro dlouhodobou prevenci p\u0159ed z\u00e1chvaty.10<\/sup>Dnes jsou mo\u017enosti l\u00e9\u010dby r\u016fznorod\u011bj\u0161\u00ed.<\/p>\n

Z\u00e1chrann\u00e1 akutn\u00ed l\u00e9\u010dba<\/strong><\/p>\n

U z\u00e1chrann\u00e9 akutn\u00ed l\u00e9\u010dby se pou\u017e\u00edv\u00e1 icatibant formou jednoduch\u00e9ho pod\u00e1n\u00ed subkut\u00e1nn\u00ed injekce pacientem samotn\u00fdm. D\u00e1le je k\u00a0dispozici tak\u00e9 plazmatick\u00fd a rekombinantn\u00ed analog inhibitoru C1.9<\/sup> Tyto dva p\u0159\u00edpravky se pod\u00e1vaj\u00ed formou injekce do \u017e\u00edly ve zdravotnick\u00e9m za\u0159\u00edzen\u00ed, p\u0159\u00edpadn\u011b i pacientem samotn\u00fdm, ov\u0161em pouze po pro\u0161kolen\u00ed zdravotnick\u00fdm pracovn\u00edkem. Spolu s\u00a0p\u0159\u00edchodem t\u011bchto mo\u017enost\u00ed do\u0161lo k\u00a0redukci hospitalizac\u00ed pacient\u016f o 75\u00a0% (z 22,78\u00a0% na 5,63\u00a0%).7<\/sup> Nicm\u00e9n\u011b akutn\u00ed z\u00e1chrann\u00e1 l\u00e9\u010dba je hrazena poji\u0161\u0165ovnou jen v\u00a0p\u0159\u00edpadech\u00a0akutn\u00edch otok\u016f obli\u010deje, d\u00fdchac\u00edch cest nebo b\u0159icha.11<\/sup> Hrazena nen\u00ed v\u00a0p\u0159\u00edpad\u011b dal\u0161\u00edch akutn\u00edch atak, nap\u0159. kon\u010detin. P\u0159itom se jedn\u00e1 o onemocn\u011bn\u00ed, kter\u00e9 m\u00e1 jako jedna ze t\u0159\u00ed skupin l\u00e9\u010dby samostatnou \u00fahradovou kategorii,12<\/sup> a i ostatn\u00ed typy atak jsou pro pacienty velmi zat\u011b\u017euj\u00edc\u00ed.<\/p>\n

Kr\u00e1tkodob\u00e1 profylaktick\u00e1 l\u00e9\u010dba<\/strong><\/p>\n

Co se t\u00fdk\u00e1 kr\u00e1tkodob\u00e9 profylaxe, ta se prov\u00e1d\u00ed p\u00e1r hodin p\u0159ed invazivn\u00edm z\u00e1krokem, jako je operace, endoskopie, trh\u00e1n\u00ed zubu \u010di porod.13<\/sup><\/p>\n

Dlouhodob\u00e1 profylaktick\u00e1 l\u00e9\u010dba<\/strong><\/p>\n

Doposud k\u00a0dlouhodob\u00e9 profylaxi l\u00e9ka\u0159i vyu\u017e\u00edvali danazol, atenuovan\u00fd androgen. D\u00e1le kyselinu tranexamovou, kter\u00e1 se pod\u00e1v\u00e1 d\u011btsk\u00fdm pacient\u016fm, nebo pokud je danazol kontraindikov\u00e1n.9<\/sup><\/p>\n

Nov\u00fd p\u0159\u00edslib modern\u00ed dlouhodob\u00e9 preventivn\u00ed l\u00e9\u010dby<\/strong><\/p>\n

V\u00fdznamn\u00fdm momentem pro pacienty i l\u00e9ka\u0159e v\u00a0\u010cesk\u00e9 republice je nov\u00fd typ preventivn\u00ed l\u00e9\u010dby heredit\u00e1rn\u00edho angioed\u00e9mu, kter\u00fd pr\u00e1v\u011b vstupuje na \u010desk\u00fd trh. Tento typ preventivn\u00ed l\u00e9\u010dby je pova\u017eov\u00e1n za zlomov\u00fd. L\u00e9\u010dba se pod\u00e1v\u00e1 ka\u017ed\u00e9 dva t\u00fddny a\u017e jednou m\u011bs\u00ed\u010dn\u011b formou subkut\u00e1nn\u00ed injekce a jej\u00edm p\u0159\u00edslibem je v\u00fdrazn\u00e9 sn\u00ed\u017een\u00ed po\u010dtu atak u pacient\u016f, v n\u011bkter\u00fdch p\u0159\u00edpadech pak i jejich \u00fapln\u00e1 absence, co\u017e je zcela pr\u016flomov\u00e9.4<\/sup><\/p>\n

Heredit\u00e1rn\u00ed angioed\u00e9m je vz\u00e1cn\u00e9 a z\u00e1va\u017en\u00e9 onemocn\u011bn\u00ed, kter\u00e9 m\u00e1 velk\u00fd vliv na kvalitu \u017eivota pacient\u016f a\u00a0mnohdy je tak\u00e9 ohro\u017euje na \u017eivot\u011b. Nov\u00e1 preventivn\u00ed l\u00e9\u010dba v\u0161ak pom\u016f\u017ee pacient\u016fm a jejich l\u00e9ka\u0159\u016fm m\u00edt onemocn\u011bn\u00ed v\u00edce pod kontrolou. Situace m\u016f\u017ee b\u00fdt tak\u00e9 p\u0159\u00edslibem doby, kdy se dan\u00e9 medic\u00ednsk\u00e9 oblasti a\u00a0specializaci dost\u00e1v\u00e1 op\u011bt v\u011bt\u0161\u00ed, zaslou\u017een\u00e9 pozornosti.<\/p>\n

 <\/p>\n

Kontakt pro m\u00e9dia: <\/strong><\/p>\n

Mark\u00e9ta Stillerov\u00e1 (Hrab\u00e1nkov\u00e1), Senior PR Manager, Havas, 702\u00a0213\u00a0341, marketa.stillerova@havaspr.com<\/a><\/p>\n

Michaela Jura\u010d\u00e1kov\u00e1, PR Executive, Havas, 602 766\u00a0398, michaela.juracakova@havaspr.com<\/a><\/p>\n

Zdroje: <\/strong><\/p>\n

    \n
  1. KR\u00c1L\u00cd\u010cKOV\u00c1, Pavl\u00edna, 2016. Heredit\u00e1rn\u00ed angioed\u00e9m a jeho l\u00e9\u010dba. Remedia<\/em> (online). 14(6), s. 362\u2013364 [cit. 12. 11. 2019]. Dostupn\u00e9 z: http:\/\/www.remedia.cz\/Okruhy-temat\/Hematologie\/Hereditarni-angioedem-a-jeho-lecba\/8-15-27S.magarticle.aspx<\/a>.<\/li>\n
  2. HANZL\u00cdKOV\u00c1, Jana, 2013. Heredit\u00e1rn\u00ed angioed\u00e9m. Medical Tribune. 1. vyd\u00e1n\u00ed, s. 5<\/li>\n
  3. Medical Tribune. Heredit\u00e1rn\u00ed angioed\u00e9m \u2013 opom\u00edjen\u00e1 diagn\u00f3za, u kter\u00e9 lze pacient\u016fm v\u00fdrazn\u011b pomoci. (online). Dostupn\u00e9 z:https:\/\/www.tribune.cz\/clanek\/40853-hereditarni-angioedem-opomijena-diagnoza-u-ktere-lze-pacientum-vyrazne-pomoci<\/a><\/li>\n
  4. BANERJI, A., RIEDL, M. A., BERNSTEIN, J. A. et al.; for HELP inestigators. Effect of lanadelumab compared with placebo on prevention of hereditary angioedema attacks: a randomized clinical trial. JAMA. 2018;320(20):2108\u20132121.<\/li>\n
  5. LITZMAN, Ji\u0159\u00ed et al., 2018. Heredit\u00e1rn\u00ed angioed\u00e9m laryngealn\u00ed ataky: data z N\u00e1rodn\u00edho registru prim\u00e1rn\u00edch imunodeficienc\u00ed. 20(2), s. 85.<\/li>\n
  6. Ob\u010dansk\u00e9 sdru\u017een\u00ed na ochranu pacient\u016f s heredit\u00e1rn\u00edm angioed\u00e9mem. O onemocn\u011bn\u00ed, p\u0159\u00edznaky a p\u0159\u00ed\u010diny. (online). Dostupn\u00e9 z: http:\/\/www.hae-imuno.cz\/priznaky-a-priciny\/<\/a><\/li>\n
  7. KR\u010cMOV\u00c1, Irena, 2017. Heredit\u00e1rn\u00ed angioed\u00e9m \u2013 trendy v l\u00e9\u010db\u011b. Intern\u00ed medic\u00edna<\/em> [online]. 9(3), s. 131\u2013137 [cit. 11. 11. 2019]. Dostupn\u00e9 z: https:\/\/www.internimedicina.cz\/pdfs\/int\/2017\/03\/06.pdf<\/a>.<\/li>\n
  8. KOV\u00c1\u010cOV\u00c1, Petra, 2019. Poji\u0161\u0165ovny mnohdy vysly\u0161\u00ed sp\u00ed\u0161e pacienty ne\u017e l\u00e9ka\u0159e. In: Pro l\u00e9ka\u0159e<\/em> [online]. 1. 5. [cit. 18. 11. 2019]. Dostupn\u00e9 z: https:\/\/www.prolekare.cz\/tema\/primarni-imunodeficience\/detail\/pojistovny-mnohdy-vyslysi-spise-pacienty-nez-lekare-112470<\/a><\/li>\n
  9. L\u00e9\u010dba heredit\u00e1rn\u00edho angioed\u00e9mu \u2013 sou\u010dasnost a budoucnost. Prol\u00e9ka\u0159e.cz. (online) Dostupn\u00e9 z: https:\/\/www.prolekare.cz\/tema\/primarni-imunodeficience\/detail\/lecba-hereditarniho-angioedemu-soucasnost-a-budoucnost-109334<\/a><\/li>\n
  10. International Patient Organization for C1 Inhibitor Deficiencies. Stav boje proti HAE v\u00a0Evrop\u011b. (online). Dostupn\u00e9 z: http:\/\/www.hae-imuno.cz\/files\/HAEi-Report-czech.pdf<\/a><\/li>\n
  11. S\u00daKL. Datab\u00e1ze l\u00e9k\u016f. (online). Dostupn\u00e9 z: http:\/\/www.sukl.cz\/modules\/medication\/detail.php?code=0500220&tab=prices<\/a><\/li>\n
  12. \u00dahradov\u00e1 vyhl\u00e1\u0161ka pro rok 2020 (ofici\u00e1ln\u00ed publikace ze sb\u00edrky z\u00e1kon\u016f), vyhl\u00e1\u0161ka \u010d. 268\/2019, p\u0159\u00edloha \u010d. 1, bod 2.2.1, str. 7<\/li>\n
  13. SOBOTKOV\u00c1, Marta, 2019. L\u00e9\u010dba heredit\u00e1rn\u00edho angioed\u00e9mu. In: Pro sestru<\/em> [online]. 19. 3. [cit. 28. 11. 2019]. Dostupn\u00e9 z: https:\/\/www.prosestru.cz\/videa\/lecba-hereditarniho-angioedemu-soucasnost-a-budoucnost-108600<\/a>.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Heredit\u00e1rn\u00ed angioed\u00e9m (HAE) je genetick\u00e1 porucha imunitn\u00edho syst\u00e9mu, kter\u00e1 se podle odhad\u016f vyskytuje v Evrop\u011b u jednoho z 50 000 a\u017e 150 000 lid\u00ed. Vyzna\u010duje se opakovan\u00fdmi epizodami otok\u016f k\u016f\u017ee a sliznic na r\u016fzn\u00fdch \u010d\u00e1stech t\u011bla. Nap\u0159\u00edklad se jedn\u00e1 o otoky b\u0159icha, kon\u010detin, obli\u010deje, hrtanu nebo mo\u010dov\u00fdch cest.1<\/sup> \u0158ad\u00ed se mezi vz\u00e1cn\u00e1 a sou\u010dasn\u011b velmi nebezpe\u010dn\u00e1 onemocn\u011bn\u00ed. V p\u0159\u00edpad\u011b nel\u00e9\u010den\u00e9 ataky v oblasti laryngu m\u016f\u017ee pacienta ohrozit i na \u017eivot\u011b. V\u010dasn\u00e1 diagnostika a vhodn\u011b zvolen\u00e1 l\u00e9\u010dba je tedy pro pacienty i jejich o\u0161et\u0159uj\u00edc\u00ed l\u00e9ka\u0159e nadm\u00edru d\u016fle\u017eit\u00e1.2<\/sup> Prvn\u00ed zm\u00ednky o heredit\u00e1rn\u00edm angioed\u00e9mu poch\u00e1zej\u00ed z roku 1876,3<\/sup> ov\u0161em za tu dobu l\u00e9\u010dba nadm\u00edru pokro\u010dila a nyn\u00ed celosv\u011btov\u011b p\u0159ich\u00e1z\u00ed modern\u00ed pr\u016flomov\u00e1 preventivn\u00ed l\u00e9\u010dba, ze kter\u00e9 mohou benefitovat i pacienti v \u010cesk\u00e9 republice.4<\/sup> <\/p>\n","protected":false},"author":48,"featured_media":8536,"menu_order":0,"template":"","meta":{"_links_to":"","_links_to_target":""},"pressroom_category":[],"pressroom_tag":[204],"class_list":["post-8529","pressroom","type-pressroom","status-publish","has-post-thumbnail","hentry","pressroom_tag-zdravi"],"yoast_head":"\nL\u00e9\u010dba heredit\u00e1rn\u00edho angioed\u00e9mu \u2013 minulost, sou\u010dasnost a zlomov\u00e1 bl\u00edzk\u00e1 budoucnost - Havas Prague<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/havas.cz\/pressroom\/lecba-hereditarniho-angioedemu-minulost-soucasnost-a-zlomova-blizka-budoucnost\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"L\u00e9\u010dba heredit\u00e1rn\u00edho angioed\u00e9mu \u2013 minulost, sou\u010dasnost a zlomov\u00e1 bl\u00edzk\u00e1 budoucnost - Havas Prague\" \/>\n<meta property=\"og:description\" content=\"Heredit\u00e1rn\u00ed angioed\u00e9m (HAE) je genetick\u00e1 porucha imunitn\u00edho syst\u00e9mu, kter\u00e1 se podle odhad\u016f vyskytuje v Evrop\u011b u jednoho z 50 000 a\u017e 150 000 lid\u00ed. 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V\u010dasn\u00e1 diagnostika a vhodn\u011b zvolen\u00e1 l\u00e9\u010dba je tedy pro pacienty i jejich o\u0161et\u0159uj\u00edc\u00ed l\u00e9ka\u0159e nadm\u00edru d\u016fle\u017eit\u00e1.2 Prvn\u00ed zm\u00ednky o heredit\u00e1rn\u00edm angioed\u00e9mu poch\u00e1zej\u00ed z roku 1876,3 ov\u0161em za tu dobu l\u00e9\u010dba nadm\u00edru pokro\u010dila a nyn\u00ed celosv\u011btov\u011b p\u0159ich\u00e1z\u00ed modern\u00ed pr\u016flomov\u00e1 preventivn\u00ed l\u00e9\u010dba, ze kter\u00e9 mohou benefitovat i pacienti v \u010cesk\u00e9 republice.4\" \/>\n<meta property=\"og:url\" content=\"https:\/\/havas.cz\/pressroom\/lecba-hereditarniho-angioedemu-minulost-soucasnost-a-zlomova-blizka-budoucnost\/\" \/>\n<meta property=\"og:site_name\" content=\"Havas Prague\" \/>\n<meta property=\"article:modified_time\" content=\"2020-10-14T08:13:14+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/havas.cz\/wp-content\/uploads\/2020\/03\/otok1200x600-0000-otoky-tvar-usta.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"8 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/havas.cz\/pressroom\/lecba-hereditarniho-angioedemu-minulost-soucasnost-a-zlomova-blizka-budoucnost\/\",\"url\":\"https:\/\/havas.cz\/pressroom\/lecba-hereditarniho-angioedemu-minulost-soucasnost-a-zlomova-blizka-budoucnost\/\",\"name\":\"L\u00e9\u010dba heredit\u00e1rn\u00edho angioed\u00e9mu \u2013 minulost, sou\u010dasnost a zlomov\u00e1 bl\u00edzk\u00e1 budoucnost - Havas Prague\",\"isPartOf\":{\"@id\":\"https:\/\/havas.cz\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/havas.cz\/pressroom\/lecba-hereditarniho-angioedemu-minulost-soucasnost-a-zlomova-blizka-budoucnost\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/havas.cz\/pressroom\/lecba-hereditarniho-angioedemu-minulost-soucasnost-a-zlomova-blizka-budoucnost\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/havas.cz\/wp-content\/uploads\/2020\/03\/otok1200x600-0000-otoky-tvar-usta.jpg\",\"datePublished\":\"2020-03-07T09:43:42+00:00\",\"dateModified\":\"2020-10-14T08:13:14+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/havas.cz\/pressroom\/lecba-hereditarniho-angioedemu-minulost-soucasnost-a-zlomova-blizka-budoucnost\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/havas.cz\/pressroom\/lecba-hereditarniho-angioedemu-minulost-soucasnost-a-zlomova-blizka-budoucnost\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/havas.cz\/pressroom\/lecba-hereditarniho-angioedemu-minulost-soucasnost-a-zlomova-blizka-budoucnost\/#primaryimage\",\"url\":\"https:\/\/havas.cz\/wp-content\/uploads\/2020\/03\/otok1200x600-0000-otoky-tvar-usta.jpg\",\"contentUrl\":\"https:\/\/havas.cz\/wp-content\/uploads\/2020\/03\/otok1200x600-0000-otoky-tvar-usta.jpg\",\"width\":1200,\"height\":600},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/havas.cz\/pressroom\/lecba-hereditarniho-angioedemu-minulost-soucasnost-a-zlomova-blizka-budoucnost\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Dom\u016f\",\"item\":\"https:\/\/havas.cz\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Pressroom\",\"item\":\"https:\/\/havas.cz\/pressroom\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"L\u00e9\u010dba heredit\u00e1rn\u00edho angioed\u00e9mu \u2013 minulost, sou\u010dasnost a zlomov\u00e1 bl\u00edzk\u00e1 budoucnost\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/havas.cz\/#website\",\"url\":\"https:\/\/havas.cz\/\",\"name\":\"Havas Prague\",\"description\":\"Agentura Havas Prague. 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